The Transplant Cancer Match Study data provide a valuable resource for research on cancer and transplantation. Study data are used for the following purposes:
- Identify cancers that occur at increased frequency in solid organ transplant recipients.
- Focus on specific cancers (including rare cancers) to identify the effects of immunosuppression, demographic characteristics, features of the transplanted organ, medical conditions, viral infections, and medications that may reflect etiology.
- Describe changes in cancer burden over time, which may reflect changes in transplantation practice.
- Describe the spectrum of cancer in subgroups of transplant recipients of particular interest.
- Identify associations with markers of immunosuppression, such as use of induction therapy.
- Assess the risk of transmission of cancer from donors to recipients.
- Identify predictors of survival following a cancer diagnosis.
- Provide information to the National Cancer Institute, the Health Resources and Services Administration, and the transplant community on cancer risk and opportunities to improve screening, prevention, and treatment of cancer.
Ideas for specific projects and collaborations related to these aims are welcome. The Transplant Cancer Match Study principal investigator is the custodian for the data. Agreements between the National Cancer Institute, the Health Resources and Services Administration, and participating registries do not allow the investigators to share the data with outside researchers. Also, the study data are complex and require the use of sophisticated data handling and statistical modeling techniques. Collaborators can use the study data at the National Cancer Institute under close supervision by the principal investigator, or can participate in analyses through review of tabulated data.
Interested collaborators should contact the Transplant Cancer Match Study principal investigator:
Eric A. Engels, MD MPH
Infections & Immunoepidemiology Branch
Division of Cancer Epidemiology and Genetics
National Cancer Institute
9609 Medical Center Dr, Room 6E226 MSC 9767
Bethesda, MD 20892